Fuel tuning from N/A to Vortech

I'm in the process of installing a Vortech supercharger on my 4.6 2v and trying to figure out lambdas I need to be running. For cruising with low boost (2-3 lb) would 1.0 lambda be sufficient and .8 lambda for 10lb wot?I also don't have the ability to change closed loop fuel on my stock ecu. Would forcing it to stay in open/cold loop be fine? With the cold loop, I have a load-by-temp axis but unsure if that will cause issues leaving it in cold loop.

You'll need some enrichment for component protection in boost. The amount required depends on fuel quality, intercooler efficiency and charge air temps, time on power etc. so there isn't a straightforward number to give, but you're on the right track. HPA has some courses on developing appropriate target AFRs which will help make those decisions.

Would any of those courses talk about open vs closed loop on a ford? Because if It’s a problem to stay open loop then I might need to bite the bullet on a Holley.

Open loop fueling in boost is common on older OE ECUs. I don't know your particular year/model's logic offhand, but there's likely a MAP or Mass Airflow threshold for open loop operation to cause the transition where you'd like it.

So it’s a 2010 f150 4.6 2v, from what I see it only enters open loop when below a set ECT. Then the open loop table has a ect x lambda x load table. So if I just set it to stay in open loop below 250F that should be fine right? Then set lambda accordingly?